Pakistan politician Imran Khan has 3 fractured vertebrae

LAHORE, Pakistan (AP) ? Prominent Pakistani politician Imran Khan is expected to make a full recovery despite fracturing three vertebrae and a rib in a dramatic fall at a political rally, his doctor said Wednesday.

Khan, a former cricket legend whose party is a leading contender in this week's national elections, toppled about 5 meters (15 feet) off a forklift Tuesday that was raising him and three guards to stage at a rally in the eastern city of Lahore. The dramatic footage was broadcast repeatedly on local TV.

The 60-year-old Khan fractured a vertebra in his neck and two in his back in the fall, said his doctor, Faisal Sultan. He also cracked a rib and cut his head, but Sultan refuted earlier reports that Khan fractured his skull.

"The most important thing out of all this is the spinal canal is intact and Mr. Imran Khan is in full control of all his limbs and his body functions," Sultan said at a press conference in Lahore. "We are very confident that all these fractures will heal with time and will heal completely and allow him to be fully, completely functional and fit as he always is."

Khan will be kept on bed rest in the hospital for at least a few more days so doctors can conduct further examinations, Sultan said. Two of the guards who feel with Khan have been treated for their injuries and discharged, while the third is still in the hospital and is scheduled to have an operation on his leg, Sultan said.

Khan's injuries will largely knock him out of the last few days of campaigning before the elections are held on May 11, although it's unclear whether he will try to address any political rallies by phone or video.

It's possible that Khan could benefit from the accident if Pakistanis choose to vote for him out of sympathy.

Hours after the fall, the charismatic politician gave an interview from his hospital bed. He was visibly shaken and had a cut on his forehead, but he was still asking people to vote for his party.

"I have done whatever I could do," Khan said. "Now you have to decide whether you want to make a new Pakistan."

One of Khan's main competitors, former Prime Minister Nawaz Sharif, suspended his campaign for a day on Wednesday out of respect for his opponent.

The fall put a damper on what has been one of Pakistan's most dynamic election campaigns. Khan earned legendary status in the country when he led the underdog national team to a 1992 cricket World Cup victory, and had injected new energy into a political system long dominated by dynasties.

He entered politics in the late 1990s but it wasn't until 2011 that his party, Pakistan Tehreek-e-Insaf, gained a widespread national following. Now his party is considered one of the three main challengers in the upcoming election.

Many analysts consider former Sharif's Pakistan Muslim League-N party to be the front runner in the election, but Khan has emerged as a wildcard. His party has dented the two-party system long dominated by the Pakistan Muslim League-N and the outgoing Pakistan People's Party and could steal votes from both.

Much of Khan's support has come from young, middle-class Pakistanis in the country's major cities, a potentially influential group. Almost half of Pakistan's more than 80 million registered voters are under the age of 35.

According to a recent poll by the Pew Research Center, 60 percent of respondents viewed Khan favorably. However, that figure dropped slightly from a year ago, and now Khan is slightly outranked by Sharif. The Pew survey, which polled 1,201 people, was conducted in March and has a margin of error of plus or minus 4.3 percent.

Khan had been setting a furious pace of rallies and election events across the country to drum up support for his campaign. Few expect him to be the next prime minster, but his party could play a role as a kingmaker or form a solid opposition in parliament.

The election will mark a historic transfer of power from one democratically elected government fulfilling its full term to another, something that has never happened in Pakistan's coup-checkered history.

But the vote has been marred by near-daily violence.

A suicide bomber detonated a car packed with explosives outside a police station in the city of Bannu in northwest Khyber Pakhtunkhwa province Wednesday, killing a policeman and two women, said police officer Rafiq Khan.

A bomb hidden in a vegetable cart exploded in a market in another northwest city, Hangu, wounding 14 people, police officer Azmat Khan said.

____

Abbot reported from Islamabad. Associated Press writers Ijaz Mohammad in Bannu, Pakistan, and Hussain Afzal in Parachinar, Pakistan, contributed to this report.

Source: http://news.yahoo.com/pakistans-imran-khan-3-fractured-vertebrae-103320473.html

7 layer dip recipe chris carter superbowl 2012 kickoff time what time is the super bowl 2012 nfl mvp lana del rey snl performance nick diaz

Grab Adobe Ideas For iOS For Free Right Here

Hot on the heels of Adobe's announcement yesterday that Creative Suite is going to get a lot more cloud, they've made Adobe Ideas, a vector-based drawing app for iOS, absolutely free. The app also received a hefty update, adding several of the Creative Cloud features announced yesterday and a slew of new brushes. Of course, there's also a few new in-app purchases to unlock full pro-level functionality, but the app was $10 yesterday, and now it's free. And if you bought it in the past three months, you can get a refund here. [iTunes]

Source: http://gizmodo.com/grab-adobe-ideas-for-ios-for-free-right-here-494040313

grammy winners obama budget woolly mammoth belize resorts nikki minaj grammy performance shel silverstein niki minaj grammy performance

Deadline Nears For Four Star Leadership Institute

DALLAS, May 6, 2013 /PRNewswire-USNewswire/ --?The May 15 deadline for nationwide applications to the prestigious Four Star Leadership Institute with General Tommy Franks is quickly approaching.

4SL is an intense week-long leadership and character development program for high school students. The students meet with politicians, authors, and national leaders, and compete in writing and debate.

The session includes air fare, room and board, and is entirely free to the 50 selected students.? Thousands of dollars in scholarships will be available to all participants.

For more information, and to apply, go to www.fourstarleader.com/.

This year's program will be conducted at Oklahoma Christian University in Edmund, Oklahoma, July 14-20.

"Our grand experiment of America can't last long in gridlock," said Gen. Franks. "We're going to have to get to a point where you can have an opinion, and I can have an opinion, and we can argue the merits of each viewpoint without being disrespectful.?

"It's long been my hope that we could mentor young people in this skill of resolving conflicts through civil discourse, rather than civil discord.? And the Four Stars of this kind of leadership are Character, Common Vision, Communication, and Caring."

Students will be chosen based on the leadership potential demonstrated in their application, references provided and a phone interview.

Three full-tuition scholarships to the University of Texas ? Arlington and $15,000 in scholarship grants will be awarded to competition winners, and every one of the 50 students who will attend Oklahoma Christian University will receive a $1,000 per year scholarship for up to four years.

Gen. Tommy Franks, former commander-in-chief of American and coalition forces in Iraq and Afghanistan, hosts the program, with Oklahoma Christian University (OC), the National Center for Policy Analysis (NCPA) and new 2013 partner the Oklahoma Council of Public Affairs (OCPA).?

SOURCE National Center for Policy Analysis

Source: http://news.yahoo.com/deadline-nears-four-star-leadership-institute-120000801.html

Wimbledon 2012 TV Schedule fourth of july IFE Fireworks 2012 4th Of July independence day BET Awards 2012 declaration of independence

Protein complex may play role in preventing many forms of cancer

May 5, 2013 ? Researchers at the Stanford University School of Medicine have identified a group of proteins that are mutated in about one-fifth of all human cancers. The finding suggests that the proteins, which are members of a protein complex that affects how DNA is packaged in cells, work to suppress the development of tumors in many types of tissues.

The broad reach of the effect of mutations in the complex, called BAF, rivals that of another well-known tumor suppressor called p53. It also furthers a growing notion that these so-called chromatin-regulatory complexes may function as much more than mere cellular housekeepers.

"Although we knew that this complex was likely to play a role in preventing cancer, we didn't realize how extensive it would be," said postdoctoral scholar Cigall Kadoch, PhD. "It's often been thought that these complexes play supportive, maintenance-like roles in the cell. But this is really changing now."

Kadoch shares lead authorship of the study with postdoctoral scholar Diana Hargreaves, PhD. Gerald Crabtree, MD, professor of developmental biology and of pathology, is the senior author of the study, published online May 5 in Nature Genetics.

Chromatin-regulatory complexes work to keep DNA tightly condensed, while also granting temporary access to certain portions for replication or to allow the expression of genes necessary for the growth or function of the cell.

Members of Crabtree's laboratory have been interested in BAF complexes and their function for many years. Recently, they reported in the journal Nature that switching subunits within these complexes can convert human fibroblasts to neurons, which points to their instructive role in development and, possibly, cancer.

"Somehow these chromatin-regulatory complexes manage to compress nearly two yards of DNA into a nucleus about one one-thousandth the size of a pinhead," said Crabtree, who is also a member of the Stanford Cancer Institute and a Howard Hughes Medical Institute investigator. "And they do this without compromising the ability of the DNA to be replicated and selectively expressed in different tissues -- all without tangling. In 1994 we reported that complexes of this type were likely to be tumor suppressors. Here we show that they are mutated in nearly 20 percent of all human malignancies thus far examined."

The researchers combined biochemical experiments with the data mining of 44 pre-existing studies to come to their conclusions, which would not have been possible without the advent of highly accurate, genome-wide DNA sequencing of individual human tumor samples. Interestingly, mutations to certain subunits, or particular combinations of mutations in the complex's many subunits, seem to herald the development of specific types of cancer -- favoring the development of ovarian versus colon cancer, for example.

The importance of the BAF complex as a tumor suppressor is further emphasized by the fact that, in some cases, a mutation in one subunit is sufficient to initiate cancer development.

"For example," said Kadoch, "a type of mutation called a chromosomal translocation in the gene encoding one of these newly identified subunits, SS18, is known to be the hallmark of a cancer called synovial sarcoma. It is clearly the driving oncogenic event and very often the sole genomic abnormality in these cancers." Kadoch and Crabtree published a study in March in Cell uncovering the mechanism and functional consequences of BAF complex perturbation in synovial sarcoma.

The startling prevalence of mutations in the BAF complex was discovered when Kadoch conducted a series of experiments to determine exactly which proteins in the cell were true subunits of the complex. (The exact protein composition of the large complex varies among cell types and species.) Kadoch used an antibody that recognized one core component to purify intact BAF complexes in various cell types, including embryonic stem cells and skin, nerve and other cells. She then analyzed the various proteins isolated by the technique.

Using this method, Kadoch identified seven proteins previously unknown to be BAF components. She and Hargreaves then turned to previously published studies in which the DNA from a variety of human tumors had been sequenced to determine how frequently any of the members of the complex were mutated.

The results, once the newly discovered members were included, were surprising: 19.6 percent of all human tumors displayed a mutation in at least one of the complex's subunits. In addition, for some types of cancers (such as synovial sarcoma), every individual tumor sample examined had a mutation in a BAF subunit. The results suggest that the BAF complex, when unmutated, plays an important protective role against the development of cancer in many different tissues.

The researchers are now focused on learning how the mutations affect the tumor-suppressing activity of the BAF complex.

"We certainly want to further our understanding of the mechanism behind these findings," said Hargreaves. "Do they promote cancer development by inhibiting the proper progression of the cell cycle? Or perhaps they affect how the complex is positioned on the DNA. We'd like to determine how to recapitulate some of these mutations experimentally to see what types of defects they introduce into the complex."

Other Stanford authors of the study include postdoctoral scholar Courtney Hodges, PhD, and former lab members Laura Elias, PhD, and Lena Ho, PhD.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/_PWPcNBi378/130505150040.htm

jennifer lawrence Oscar Winners 2013 quentin tarantino jessica chastain jessica chastain oscars jane fonda

Rolling Stones launch tour with energetic set

LOS ANGELES (AP) ? The Rolling Stones must have passed through a time machine before taking the Staples Center stage to kick off their "50 and Counting" anniversary tour.

Mick Jagger, Keith Richards, Ronnie Wood and Charlie Watts delivered a rousing set Friday night with the kind of youthful energy and musical verve they displayed decades ago. Their faces showed their age, but their performance did not, with a nonstop, more than two-hour set packed with well-worn hits.

Jagger and Richards are each 69 years old, and Watts is 71, but they transformed into their younger selves for the night. (Wood is the baby of the band at 65.)

Jagger might not hit all the notes he once did, but he still busted out his almost spastic, serpentine dance moves on song after song. He's impossibly thin, and his spine showed through the light shirt he wore.

Staples Center was packed to capacity for the concert, the first of 17 dates the Stones are set to play throughout the United States.

The stage was modeled after the band's iconic logo, with lips and teeth above the stage and a tongue-shaped platform that extended into the crowd.

A video of famous folks sharing their favorite Rolling Stones memories played before the band took the stage, with Johnny Depp, Martin Scorsese, Perry Farrell and others reminiscing about their favorite tunes.

Actress Cate Blanchett recalled "just how skinny they were."

"It really, really pisses me off," she said.

(Honestly, the Stones could produce a best-selling diet book ? the members are as slim as they were as aspiring rockers in the 1960s.)

Other videos showed the aging rockers as young men.

Jack Nicholson was among the stars in the audience, and fans welcomed him with a round of applause as he took his seat.

"It was either us or the Lakers, so now you got us," Jagger said early in the show, referring to the basketball playoffs that forced the band to postpone its opening concert from Thursday to Friday.

"It doesn't matter to Jack Nicholson," Jagger continued, "because he was coming to both of them."

Nicholson wasn't the only star in the house. Gwen Stefani, wearing long blond hair and a bedazzled Rolling Stones tank top, joined the group onstage to sing "Wild Horses."

"I've got to get one of these T-shirts," Jagger said, admiring her top.

Keith Urban played guitar and sang backup on "Respectable." Former Stones member Mick Taylor added guitar to "Midnight Rambler."

Richards sang a pair of tunes: "Happy" and "Before They Make Me Run." Jagger also played guitar and harmonica, and came out in a floor-length marabou cape to perform "Sympathy for the Devil."

"We first played in LA in 1965," Jagger said. "Thank you for keeping on coming to see us."

The Rolling Stones' tour continues through June 21.

___

Follow AP Entertainment Writer Sandy Cohen on Twitter: www.twitter.com/APSandy.

___

Online:

www.rollingstones.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-05-04-Music-Rolling%20Stones/id-af2d28dc7d824b2094edb1f9e3534b97

What is a Jesuit pi day Samsung Galaxy S4 St Francis Anquan Boldin Pope Benedict Jesuits

Tesla CEO amends Model S financing deal after criticism

By Deepa Seetharaman

DETROIT (Reuters) - Tesla Motors Inc, the automaker led by billionaire Elon Musk, overhauled financing strategy for the Model S electric sedan in response to criticism that its initial plan last month overstated the potential cost savings.

Changes include allowing buyers 72 months, instead of 63, to repay loans, lowering monthly costs by more than one-fourth. Tesla also guaranteed that the resale value of the Model S would top other luxury cars in its segment.

"We looked at it and decided we were wrong," Chief Executive Musk told reporters during a conference call on Friday. "Other people were right, and we needed to fix it."

The financing deal is intended to make the Model S electric sedan, which starts around $70,000 before a $7,500 tax credit, more affordable.

But Tesla got flack from critics who said the company was too aggressive in saying payments could be as low as $500 a month. The company's online payment calculator valued time saved filling up on gas at $100 an hour.

The automaker also drew criticism for pegging the resale value of the Model S to the Mercedes S class of sedans.

Tesla has since changed the default settings of its online payment calculators to be more conservative. The calculator now reflects only potential gas savings and assumes premium gas will be below $5 a gallon over the next three years.

Tesla will also guarantee that the resale value of the Model S will be higher than comparable luxury vehicles from BMW , Audi , Mercedes , Lexus or Jaguar , the company said.

"We're guaranteeing that the resale value in three years will be better than that of any of the major premium sedan brands," Musk told reporters.

Without taking into account gas savings, the monthly cost of owning a Model S will be around $800, down from $1,100, Musk said during the call. Including gas savings, the cost will be between $500 and $600 a month.

If 70 percent of the miles put on the car are for business purposes, the depreciation benefits cuts the "effective monthly cost" of owning a Model S down to $350, Tesla said.

The new financing deal will be extended to those who financed their Model S purchases over the last month. At least one-fifth of buyers over the last month made use of the financing deal, but Musk told reporters that he expects that figure to go as high as 70 percent.

(Reporting by Deepa Seetharaman; editing by Gunna Dickson)

Source: http://news.yahoo.com/tesla-ceo-amends-model-financing-deal-criticism-200436877.html

jeremy lin game winner chocolate covered strawberries shrimp scampi kate upton si cover lobster recipes hearts flower delivery

Acer Aspire R7 Hands On: We're Not Quite Ready for This Kind of Crazy

Can we start by saying the R7 is nuts, and that that's totally great? Because it is, it's great that Acer's doing this weird new thing that doesn't exactly make sense, just to see if it works.

The very first thing you notice about the R7 becomes at once one of the the most and least important things about using it: the Ezel hinge. It's very godo at some of its jobs, and not very good at others. The problem is that it's got more to dot han the typical hinge. It's got to not only open and close like a typical laptop, but adjust forward and backward like an actual easel. Angling the screen with the top part of the hinge feels perfect. Tilting and flipping it all the way around to the other side (a novelty, but one you might actually use) takes just the right amount of force. But while you'll appreciate the back/bottom part of the hinge being so rigid while you're using the R7 as a touchscreen monitor?there's no wobble at all?it makes opening and closing the lid, and further, adjusting it forward or backwards, pretty inconvenient. That sounds like a small detail, and plenty of people won't mind a clumsy, two-handed process adjusting the hinge, but it's something you'll be doing quite often, given the trackpad placement.

About that. I'm not sure it makes that much ergonomic sense. The unit I used was on a raised box?about the level of a standing desk?and I didn't get to sit down with it on my lap. But I got the sense that the preferred use method is going to be with the screen mostly covering up the trackpad. That's where you'll see some benefit from the design, but it's still questionable, given standard placement would allow your hands to still be near the screen, but still have access tot he trackpad. And on the lap, where the wrist rests can also act as a stabilizing mechanism, this makes even less sense. There's definitely a type of user who's going to love this, though.

The most disappointing thing about the R7, though, is that despite its naming lineage, it seems like a big step backward from the S7 in build quality. It's sturdy, to be sure, but its plasticy and uncomfortable keyboard are a step back from the S7's, which was polarizing as far as usability, but always felt and looked premium. The 1080p 15-inch screen is very pretty, though large enough to be goofy when folded all the way down in tablet mode. It's not overly heavy, for a 15-inch device, but it ain't light, either.

The R7 is pretty clearly aimed at people who will be using it at a desk all day, and who have some compelling reason to be using touch over other input methods. It doesn't really make much sense for anyone else. For now, that first group is small enough to not register on a wide scale. That might not be the case in the future, but for now, the R7 really isn't for everyone.

Source: http://gizmodo.com/acer-aspire-r7-hands-on-crazy-is-the-future-but-not-q-489120346

amanda bynes dui ghost ship tiger woods masters jet crash virginia beach petrino clayton kershaw tyler perry