Friday, June 21, 2013

Florida State's future star

June, 19, 2013

Jun 19

5:00

PM ET

The theme this week at ESPN.com has been looking at the future, trying to predict which teams will be the best in the country three years from now.

On Tuesday, we revealed the College Football Future Power Rankings, and the methodology used to predict them. In the latest ESPNU College Football Podcast, colleagues Ivan Maisel and Travis Haney broke down the ranking, and guru Phil Steele joined the show to help preview the season.

It's impossible to predict a team's future success, though, without knowing a little bit about the recruiting, and expert Tom Luginbill today identified 10 future stars -- including one from Florida State. Check it out to see who might be a rising star on the Noles' D.

Source: http://espn.go.com/blog/acc/post/_/id/56736/fsus-future-star

Alison Pill Sam Bacile sprint britney spears At&t Wireless 9/11 Jerry Lawler

Tuesday, June 18, 2013

Cassini probe to take photo of Earth from deep space

June 18, 2013 ? NASA's Cassini spacecraft, now exploring Saturn, will take a picture of our home planet from a distance of hundreds of millions of miles on July 19. NASA is inviting the public to help acknowledge the historic interplanetary portrait as it is being taken.

Earth will appear as a small, pale blue dot between the rings of Saturn in the image, which will be part of a mosaic, or multi-image portrait, of the Saturn system Cassini is composing.

"While Earth will be only about a pixel in size from Cassini's vantage point 898 million [1.44 billion kilometers] away, the team is looking forward to giving the world a chance to see what their home looks like from Saturn," said Linda Spilker, Cassini project scientist at NASA's Jet Propulsion Laboratory in Pasadena, Calif. "We hope you'll join us in waving at Saturn from Earth, so we can commemorate this special opportunity."

Cassini will start obtaining the Earth part of the mosaic at 2:27 p.m. PDT (5:27 p.m. EDT or 21:27 UTC) and end about 15 minutes later, all while Saturn is eclipsing the sun from Cassini's point of view. The spacecraft's unique vantage point in Saturn's shadow will provide a special scientific opportunity to look at the planet's rings. At the time of the photo, North America and part of the Atlantic Ocean will be in sunlight.

Unlike two previous Cassini eclipse mosaics of the Saturn system in 2006, which captured Earth, and another in 2012, the July 19 image will be the first to capture the Saturn system with Earth in natural color, as human eyes would see it. It also will be the first to capture Earth and its moon with Cassini's highest-resolution camera. The probe's position will allow it to turn its cameras in the direction of the sun, where Earth will be, without damaging the spacecraft's sensitive detectors.

"Ever since we caught sight of the Earth among the rings of Saturn in September 2006 in a mosaic that has become one of Cassini's most beloved images, I have wanted to do it all over again, only better," said Carolyn Porco, Cassini imaging team lead at the Space Science Institute in Boulder, Colo. "This time, I wanted to turn the entire event into an opportunity for everyone around the globe to savor the uniqueness of our planet and the preciousness of the life on it."

Porco and her imaging team associates examined Cassini's planned flight path for the remainder of its Saturn mission in search of a time when Earth would not be obstructed by Saturn or its rings. Working with other Cassini team members, they found the July 19 opportunity would permit the spacecraft to spend time in Saturn's shadow to duplicate the views from earlier in the mission to collect both visible and infrared imagery of the planet and its ring system.

"Looking back towards the sun through the rings highlights the tiniest of ring particles, whose width is comparable to the thickness of hair and which are difficult to see from ground-based telescopes," said Matt Hedman, a Cassini science team member based at Cornell University in Ithaca, N.Y., and a member of the rings working group. "We're particularly interested in seeing the structures within Saturn's dusty E ring, which is sculpted by the activity of the geysers on the moon Enceladus, Saturn's magnetic field and even solar radiation pressure."

This latest image will continue a NASA legacy of space-based images of our fragile home, including the 1968 "Earthrise" image taken by the Apollo 8 moon mission from about 240,000 miles (380,000 kilometers) away and the 1990 "Pale Blue Dot" image taken by Voyager 1 from about 4 billion miles (6 billion kilometers) away.

The Cassini-Huygens mission is a cooperative project of NASA, the European Space Agency and the Italian Space Agency. JPL manages the Cassini-Huygens mission for NASA's Science Mission Directorate in Washington, and designed, developed and assembled the Cassini orbiter and its two onboard cameras. The imaging team consists of scientists from the United States, the United Kingdom, France and Germany. The imaging operations center is based at the Space Science Institute in Boulder, Colo.

To learn more about the public outreach activities associated with the taking of the image, visit: http://saturn.jpl.nasa.gov/waveatsaturn .

For more information about Cassini, visit http://www.nasa.gov/cassini and http://saturn.jpl.nasa.gov .

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/UCf8F3Ny_VI/130618161951.htm

trailblazers

Israel PM: Sanctions on Iran should increase

JERUSALEM (AP) ? Israel on Sunday warned the international community against easing sanctions on Iran following the election of a reformist-backed president, saying the country's nuclear efforts remain firmly in the hands of Iran's extremist ruling clerics.

Prime Minister Benjamin Netanyahu issued the warning a day after the surprise victory by Hasan Rowhani. Although Rowhani is considered a relative moderate and had the backing of Iranian reformists, Supreme Leader Ayatollah Ali Khamenei is the ultimate authority on all state matters and key security policy decisions, including nuclear efforts, defense and foreign affairs, remain in the hands of Khamenei and his powerful protectors, the Revolutionary Guard.

Netanyahu noted that the Iranian clerics disqualified candidates they disagreed with from running in the election. He said the international community must not get caught in "wishful thinking" and ease the pressure on Tehran, saying "Iran will be tested by its deeds."

Israel considers a nuclear-armed Iran to be an existential threat, citing Iranian calls for Israel's destruction, its support for anti-Israel militant groups and its missile and nuclear technology.

Tehran insists its nuclear program is peaceful, a claim that Israel and many Western countries reject.

Netanyahu said that sanctions on Iran should be increased. "The more pressure increases on Iran, so will the chance of ending Iran's nuclear program, which remains the biggest threat to world peace," Netanyahu said.

Israeli President Shimon Peres took a softer line. While Peres said it was too early to make predictions, he felt the vote was a clear sign of dissatisfaction with Iran's hard-line leadership and its outgoing president, Mahmoud Ahmadinejad.

"More than half of Iranians, in their own way, in my judgment, protested against an impossible leadership," Peres told The Associated Press. "Ahmadinejad spent hundreds of billions of dollars to build an idol of uranium. What for? He brought down the people the people on their knees. The economy is destroyed. Children don't have enough food. Youngsters are leaving the country. Iran became a center of terror, they hang people, they arrest people. What for?"

He said the biggest loser in the vote was Khamenei. "It is clearly a voice of the people and a voice that says, 'We don't agree with this group of leaders,'" Peres said.

Israel has said that it prefers diplomacy and sanctions to end Iran's nuclear program but has hinted that military action would be an option if peaceful attempts fail. It has called on the international community to issue a clear ultimatum to Iran to curb its nuclear program.

Some Israeli analysts felt having a more moderate Iranian president might make the Islamic Republic harder for Israel to deal with.

Meir Litvak, head of Iranian studies at Tel Aviv University, told Israel Army Radio that Rowhani's "smiley face to the west" might make the option of military action less likely.

In contrast, Uzi Arad, Netanyahu's former security adviser, said that Rowhani's taking over might be good for Israel.

"It's true it might be easier to have an unstable, screaming and vulgar character like Ahmadinejad. but at the end of the day it might be better to have a character that you can deter and can convince via pressure to get the desired result," Arad said.

Arad told Israel Radio that it was a good sign that millions of Iranians voted for a candidate who "explicitly spoke about acting to ease sanctions and strive for talks with the West."

Source: http://news.yahoo.com/israel-pm-sanctions-iran-increase-090537956.html

jcpenney toys r us toys r us kohls target target walmart

Monday, June 17, 2013

Predators affect the carbon cycle, study shows

June 17, 2013 ? A new study shows that the predator-prey relationship can affect the flow of carbon through an ecosystem. This previously unmeasured influence on the environment may offer a new way of looking at biodiversity management and carbon storage for climate change.

The study, conducted by researchers at the Yale School of Forestry & Environmental Studies, comes out this week in the Proceedings of the National Academy of Sciences. It looks at the relationship between grasshoppers and spiders -- herbivores and predators in the study's food chain -- and how it affects the movement of carbon through a grassland ecosystem. Carbon, the basic building block of all organic tissue, moves through the food chain at varying speeds depending on whether it's being consumed or being stored in the bodies of plants. However, this pathway is seldom looked at in terms of specific animal responses like fear from predation.

"We're discovering that predators are having important effects on shaping the make-up of ecosystems," says Dr. Oswald Schmitz, professor of ecology and one of the co-authors of the study. "But we've not really spent a lot of time measuring how that translates into other functions like nutrient cycling and recycling."

The researchers manipulated the food chains of grassland ecosystem to see how the levels of carbon would change over time. Dr. Schmitz and his team created several controlled ecosystems: some that contained only native grasses and herbs, others that had plants and an herbivore grasshopper, and some others that had plants and herbivores along with a carnivore spider species -- all three tiers of the food chain. In addition, a form of traceable carbon dioxide was injected into sample cages covered with Plexiglas, which allowed the team to track the carbon levels by periodically taking leaf, root, and dead animal samples.

The study found that the presence of spiders drove up the rate of carbon uptake by the plants by about 1.4 times more than when just grasshoppers were present and by 1.2 more times than when no animals were present. It was also revealed that the pattern of carbon storage in the plants changed when both herbivores and carnivores were present. The grasshoppers apparently were afraid of being eaten by the spiders and consumed less plant matter when the predators were around. The grasshoppers also shifted towards eating more herbs instead of grass under fearful scenarios.

At the same time, the grasses stored more carbon in their roots in a response to being disturbed at low levels when both herbivores and carnivores were present. In cases where only herbivores were present, the plants stored less carbon overall, likely due to the more intense eating habits of the herbivores that put pressure on plants to reduce their storage and breathe out carbon more. These stress impacts, then, caused both the plants and the herbivores to change their behaviors and change the composition of their local environment.

This has significance for biodiversity conservation and ecosystem management. Although the study was carried out on a small scale, it could inform practices done in much larger areas. Places such as the Alaskan wilderness, for example, are home to animals that have the same predator-and-prey dynamics that drive the carbon cycle, and so protecting lands and storing carbon could be linked at the same time. Appreciating the role of predators is also important currently, given that top predators are declining at rates faster than that of many other species in global trends of biodiversity loss.

"It's going to force some thinking about the vital roles of animals in regulating carbon," concludes Dr. Schmitz, pointing to the fact that the UN's body of scientific experts who study climate change don't consider these multiplier effects in their models. "People are arguing for a paradigm change."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/G75cAhhGpI0/130617160902.htm

tony robbins bon iver abraham lincoln vampire hunter their eyes were watching god lara logan manu ginobili sports illustrated swimsuit 2012

Thursday, June 13, 2013

Thai Muslims debate their future as peace talks raise hope

By Amy Sawitta Lefevre

PATTANI, Thailand (Reuters) - Huddled in a room on the periphery of a university campus in the southern Thai province of Pattani, Muslim students debate ideas that have long been considered inflammatory or even treasonous.

An insurgency by shadowy Muslim fighters in predominantly Buddhist Thailand's three southernmost provinces has claimed 5,700 lives since 2004.

Just a few hundred kilometers from tourist beaches, the conflict rarely hits the headlines but the failure to stamp it out is an embarrassment for a country that prides itself on being a developed, international business and travel hub.

There are signs that the government has become more conciliatory since it agreed to hold talks in February with the Barisan Revolusi Nasional (BRN), a major rebel group.

The student gathering this month at the university and debate of concepts such as autonomy would have been rare, if not impossible, a few years ago. Those present would have risked being detained on charges of sedition.

The Thai constitution sets out that the country's territory is indivisible and talk of separatism is tantamount to treason.

Few details have emerged from two preliminary rounds of peace talks, brokered by neighboring Malaysia, between the government and the BRN. Some rebels have called for a degree of self-rule.

On Wednesday, Thai officials will sit down for a third round of talks with the BRN to try to resolve Southeast Asia's deadliest internal conflict.

Despite hopes for change that the talks have brought, those attending the student gathering were still nervous.

"There is no guarantee we will not be blacklisted after this meeting," said one student who did not want to be identified.

"Someone could be a spy and report us, but our need to talk has overcome our fear."

Muslims in the three provinces have chafed under the rule of faraway Bangkok since Thailand annexed what was then an Islamic sultanate a century ago.

Generations of men have fought the state and the latest and most serious violence erupted in the early 2000s.

But analysts say incremental changes are taking place and have gathered momentum since the talks began. Frustration once expressed with graffiti daubed on walls after dark is now being vented openly among a growing network of civic groups.

They have opened discussion in meetings and on social media, fuelling debate about the political aspirations of the region's ethnic Malay, Muslim population.

"For a long time, the Thai state's interest was to consolidate control of the border states," Thomas Parks, regional director for conflict and governance at the Asia Foundation, a U.S.-based development organization, told Reuters.

"The word 'autonomy' was a bad word, but now there's open discussion about it."

Srisompob Jitpiromsri of the Deep South Watch think-tank said he also saw a change in government attitudes.

"The mindset of many of the policy-makers is different, they have become more accepting of the demands of the local population," Srisompob said.

"There is optimism."

"SAME RIGHTS NOT SEPARATISM"

The mayor of Yala town, Pongsak Yingcharoen, said the talks had raised expectations.

"Locals expected the violence to decrease when talks began. That didn't happen, so now they are trying to better understand this peace process," Pongsak said.

For years, the state has worked to instill a strong sense of Thai nationalism in the region's Malay-speaking population and symbols of "Thainess" pervade. The national anthem blares out of public speakers in the morning and at night.

Many Muslims say harsh government assimilation policies have led to the suppression of their religion, language and culture.

Army checkpoints dot the roads through a picturesque region rich in rubber yet bypassed by Thailand's economic boom. Pattani, along with neighboring Yala and Narathiwat provinces, are among Thailand's least developed areas with some of the lowest education levels.

Thailand's powerful military, which has 60,000 troops in the region, has been lukewarm about talks that could confer legitimacy on an armed movement the generals have dismissed as more criminal than political.

As some feared, the talks also appear to be encouraging ethnic Malay Muslims to express political aspirations Bangkok has long viewed as disloyal.

"People have to watch themselves when talking about separatism, but we won't detain them," said Pramote Prom-in, an army spokesman. "We understand some young people are hot-headed."

While the militants are often described as separatists, many southerners acknowledge that creating a tiny Islamic republic sandwiched between Thailand and Malaysia is unrealistic.

"Most people here aren't after a separate state, they just want to have the same rights as Buddhists," said Romuelah Saeyeh whose husband, Muhamad Anwar Ismail Hajiteh, a freelance journalist, was sentenced to 12 years in prison in May for being a member of the BRN rebel group.

The government of Prime Minister Yingluck Shinawatra has been credited for giving dialogue a chance.

Critics say her influential brother, former premier Thaksin Shinawatra, has become involved in trying to end the conflict because he is aiming to boost his standing as he plots a return to the country, and perhaps to power, from self-imposed exile.

Thaksin was widely blamed for exacerbating the conflict with harsh tactics when he was in power, including the death in 2004 of 78 Muslim protesters.

Thai security chief and Thaksin loyalist Paradorn Pattanathabutr, a key figure in the talks, told Reuters Thaksin had met separatists in Malaysia. Thaksin denied that.

Shintaro Hara, a Malay-language professor at Prince of Songkhla University in Pattani, said Bangkok politics were not a factor for most people in the south.

"Thaksin's involvement is secondary, people are just glad to see talks happening," he said.

"We cannot afford more corpses, our graveyards are already full. If we miss this chance, when will the next one come?"

(Editing by Robert Birsel)

Source: http://news.yahoo.com/thai-muslims-debate-future-peace-talks-raise-hope-210750821.html

katie couric good morning america the rock vs john cena acm awards 2012 january jones ncaa final game reba mcentire acm awards

Wednesday, May 8, 2013

Pakistan politician Imran Khan has 3 fractured vertebrae

LAHORE, Pakistan (AP) ? Prominent Pakistani politician Imran Khan is expected to make a full recovery despite fracturing three vertebrae and a rib in a dramatic fall at a political rally, his doctor said Wednesday.

Khan, a former cricket legend whose party is a leading contender in this week's national elections, toppled about 5 meters (15 feet) off a forklift Tuesday that was raising him and three guards to stage at a rally in the eastern city of Lahore. The dramatic footage was broadcast repeatedly on local TV.

The 60-year-old Khan fractured a vertebra in his neck and two in his back in the fall, said his doctor, Faisal Sultan. He also cracked a rib and cut his head, but Sultan refuted earlier reports that Khan fractured his skull.

"The most important thing out of all this is the spinal canal is intact and Mr. Imran Khan is in full control of all his limbs and his body functions," Sultan said at a press conference in Lahore. "We are very confident that all these fractures will heal with time and will heal completely and allow him to be fully, completely functional and fit as he always is."

Khan will be kept on bed rest in the hospital for at least a few more days so doctors can conduct further examinations, Sultan said. Two of the guards who feel with Khan have been treated for their injuries and discharged, while the third is still in the hospital and is scheduled to have an operation on his leg, Sultan said.

Khan's injuries will largely knock him out of the last few days of campaigning before the elections are held on May 11, although it's unclear whether he will try to address any political rallies by phone or video.

It's possible that Khan could benefit from the accident if Pakistanis choose to vote for him out of sympathy.

Hours after the fall, the charismatic politician gave an interview from his hospital bed. He was visibly shaken and had a cut on his forehead, but he was still asking people to vote for his party.

"I have done whatever I could do," Khan said. "Now you have to decide whether you want to make a new Pakistan."

One of Khan's main competitors, former Prime Minister Nawaz Sharif, suspended his campaign for a day on Wednesday out of respect for his opponent.

The fall put a damper on what has been one of Pakistan's most dynamic election campaigns. Khan earned legendary status in the country when he led the underdog national team to a 1992 cricket World Cup victory, and had injected new energy into a political system long dominated by dynasties.

He entered politics in the late 1990s but it wasn't until 2011 that his party, Pakistan Tehreek-e-Insaf, gained a widespread national following. Now his party is considered one of the three main challengers in the upcoming election.

Many analysts consider former Sharif's Pakistan Muslim League-N party to be the front runner in the election, but Khan has emerged as a wildcard. His party has dented the two-party system long dominated by the Pakistan Muslim League-N and the outgoing Pakistan People's Party and could steal votes from both.

Much of Khan's support has come from young, middle-class Pakistanis in the country's major cities, a potentially influential group. Almost half of Pakistan's more than 80 million registered voters are under the age of 35.

According to a recent poll by the Pew Research Center, 60 percent of respondents viewed Khan favorably. However, that figure dropped slightly from a year ago, and now Khan is slightly outranked by Sharif. The Pew survey, which polled 1,201 people, was conducted in March and has a margin of error of plus or minus 4.3 percent.

Khan had been setting a furious pace of rallies and election events across the country to drum up support for his campaign. Few expect him to be the next prime minster, but his party could play a role as a kingmaker or form a solid opposition in parliament.

The election will mark a historic transfer of power from one democratically elected government fulfilling its full term to another, something that has never happened in Pakistan's coup-checkered history.

But the vote has been marred by near-daily violence.

A suicide bomber detonated a car packed with explosives outside a police station in the city of Bannu in northwest Khyber Pakhtunkhwa province Wednesday, killing a policeman and two women, said police officer Rafiq Khan.

A bomb hidden in a vegetable cart exploded in a market in another northwest city, Hangu, wounding 14 people, police officer Azmat Khan said.

____

Abbot reported from Islamabad. Associated Press writers Ijaz Mohammad in Bannu, Pakistan, and Hussain Afzal in Parachinar, Pakistan, contributed to this report.

Source: http://news.yahoo.com/pakistans-imran-khan-3-fractured-vertebrae-103320473.html

7 layer dip recipe chris carter superbowl 2012 kickoff time what time is the super bowl 2012 nfl mvp lana del rey snl performance nick diaz

Grab Adobe Ideas For iOS For Free Right Here

Hot on the heels of Adobe's announcement yesterday that Creative Suite is going to get a lot more cloud, they've made Adobe Ideas, a vector-based drawing app for iOS, absolutely free. The app also received a hefty update, adding several of the Creative Cloud features announced yesterday and a slew of new brushes. Of course, there's also a few new in-app purchases to unlock full pro-level functionality, but the app was $10 yesterday, and now it's free. And if you bought it in the past three months, you can get a refund here. [iTunes]

Source: http://gizmodo.com/grab-adobe-ideas-for-ios-for-free-right-here-494040313

grammy winners obama budget woolly mammoth belize resorts nikki minaj grammy performance shel silverstein niki minaj grammy performance

Monday, May 6, 2013

Deadline Nears For Four Star Leadership Institute

DALLAS, May 6, 2013 /PRNewswire-USNewswire/ --?The May 15 deadline for nationwide applications to the prestigious Four Star Leadership Institute with General Tommy Franks is quickly approaching.

4SL is an intense week-long leadership and character development program for high school students. The students meet with politicians, authors, and national leaders, and compete in writing and debate.

The session includes air fare, room and board, and is entirely free to the 50 selected students.? Thousands of dollars in scholarships will be available to all participants.

For more information, and to apply, go to www.fourstarleader.com/.

This year's program will be conducted at Oklahoma Christian University in Edmund, Oklahoma, July 14-20.

"Our grand experiment of America can't last long in gridlock," said Gen. Franks. "We're going to have to get to a point where you can have an opinion, and I can have an opinion, and we can argue the merits of each viewpoint without being disrespectful.?

"It's long been my hope that we could mentor young people in this skill of resolving conflicts through civil discourse, rather than civil discord.? And the Four Stars of this kind of leadership are Character, Common Vision, Communication, and Caring."

Students will be chosen based on the leadership potential demonstrated in their application, references provided and a phone interview.

Three full-tuition scholarships to the University of Texas ? Arlington and $15,000 in scholarship grants will be awarded to competition winners, and every one of the 50 students who will attend Oklahoma Christian University will receive a $1,000 per year scholarship for up to four years.

Gen. Tommy Franks, former commander-in-chief of American and coalition forces in Iraq and Afghanistan, hosts the program, with Oklahoma Christian University (OC), the National Center for Policy Analysis (NCPA) and new 2013 partner the Oklahoma Council of Public Affairs (OCPA).?

SOURCE National Center for Policy Analysis

Source: http://news.yahoo.com/deadline-nears-four-star-leadership-institute-120000801.html

Wimbledon 2012 TV Schedule fourth of july IFE Fireworks 2012 4th Of July independence day BET Awards 2012 declaration of independence

Sunday, May 5, 2013

Protein complex may play role in preventing many forms of cancer

May 5, 2013 ? Researchers at the Stanford University School of Medicine have identified a group of proteins that are mutated in about one-fifth of all human cancers. The finding suggests that the proteins, which are members of a protein complex that affects how DNA is packaged in cells, work to suppress the development of tumors in many types of tissues.

The broad reach of the effect of mutations in the complex, called BAF, rivals that of another well-known tumor suppressor called p53. It also furthers a growing notion that these so-called chromatin-regulatory complexes may function as much more than mere cellular housekeepers.

"Although we knew that this complex was likely to play a role in preventing cancer, we didn't realize how extensive it would be," said postdoctoral scholar Cigall Kadoch, PhD. "It's often been thought that these complexes play supportive, maintenance-like roles in the cell. But this is really changing now."

Kadoch shares lead authorship of the study with postdoctoral scholar Diana Hargreaves, PhD. Gerald Crabtree, MD, professor of developmental biology and of pathology, is the senior author of the study, published online May 5 in Nature Genetics.

Chromatin-regulatory complexes work to keep DNA tightly condensed, while also granting temporary access to certain portions for replication or to allow the expression of genes necessary for the growth or function of the cell.

Members of Crabtree's laboratory have been interested in BAF complexes and their function for many years. Recently, they reported in the journal Nature that switching subunits within these complexes can convert human fibroblasts to neurons, which points to their instructive role in development and, possibly, cancer.

"Somehow these chromatin-regulatory complexes manage to compress nearly two yards of DNA into a nucleus about one one-thousandth the size of a pinhead," said Crabtree, who is also a member of the Stanford Cancer Institute and a Howard Hughes Medical Institute investigator. "And they do this without compromising the ability of the DNA to be replicated and selectively expressed in different tissues -- all without tangling. In 1994 we reported that complexes of this type were likely to be tumor suppressors. Here we show that they are mutated in nearly 20 percent of all human malignancies thus far examined."

The researchers combined biochemical experiments with the data mining of 44 pre-existing studies to come to their conclusions, which would not have been possible without the advent of highly accurate, genome-wide DNA sequencing of individual human tumor samples. Interestingly, mutations to certain subunits, or particular combinations of mutations in the complex's many subunits, seem to herald the development of specific types of cancer -- favoring the development of ovarian versus colon cancer, for example.

The importance of the BAF complex as a tumor suppressor is further emphasized by the fact that, in some cases, a mutation in one subunit is sufficient to initiate cancer development.

"For example," said Kadoch, "a type of mutation called a chromosomal translocation in the gene encoding one of these newly identified subunits, SS18, is known to be the hallmark of a cancer called synovial sarcoma. It is clearly the driving oncogenic event and very often the sole genomic abnormality in these cancers." Kadoch and Crabtree published a study in March in Cell uncovering the mechanism and functional consequences of BAF complex perturbation in synovial sarcoma.

The startling prevalence of mutations in the BAF complex was discovered when Kadoch conducted a series of experiments to determine exactly which proteins in the cell were true subunits of the complex. (The exact protein composition of the large complex varies among cell types and species.) Kadoch used an antibody that recognized one core component to purify intact BAF complexes in various cell types, including embryonic stem cells and skin, nerve and other cells. She then analyzed the various proteins isolated by the technique.

Using this method, Kadoch identified seven proteins previously unknown to be BAF components. She and Hargreaves then turned to previously published studies in which the DNA from a variety of human tumors had been sequenced to determine how frequently any of the members of the complex were mutated.

The results, once the newly discovered members were included, were surprising: 19.6 percent of all human tumors displayed a mutation in at least one of the complex's subunits. In addition, for some types of cancers (such as synovial sarcoma), every individual tumor sample examined had a mutation in a BAF subunit. The results suggest that the BAF complex, when unmutated, plays an important protective role against the development of cancer in many different tissues.

The researchers are now focused on learning how the mutations affect the tumor-suppressing activity of the BAF complex.

"We certainly want to further our understanding of the mechanism behind these findings," said Hargreaves. "Do they promote cancer development by inhibiting the proper progression of the cell cycle? Or perhaps they affect how the complex is positioned on the DNA. We'd like to determine how to recapitulate some of these mutations experimentally to see what types of defects they introduce into the complex."

Other Stanford authors of the study include postdoctoral scholar Courtney Hodges, PhD, and former lab members Laura Elias, PhD, and Lena Ho, PhD.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/_PWPcNBi378/130505150040.htm

jennifer lawrence Oscar Winners 2013 quentin tarantino jessica chastain jessica chastain oscars jane fonda

Rolling Stones launch tour with energetic set

(AP) ? The Rolling Stones must have passed through a time machine before taking the Staples Center stage to kick off their "50 and Counting" anniversary tour.

Mick Jagger, Keith Richards, Ronnie Wood and Charlie Watts delivered a rousing set Friday night with the kind of youthful energy and musical verve they displayed decades ago. Their faces showed their age, but their performance did not, with a nonstop, more than two-hour set packed with well-worn hits.

Jagger and Richards are each 69 years old, and Watts is 71, but they transformed into their younger selves for the night. (Wood is the baby of the band at 65.)

Jagger might not hit all the notes he once did, but he still busted out his almost spastic, serpentine dance moves on song after song. He's impossibly thin, and his spine showed through the light shirt he wore.

Staples Center was packed to capacity for the concert, the first of 17 dates the Stones are set to play throughout the United States.

The stage was modeled after the band's iconic logo, with lips and teeth above the stage and a tongue-shaped platform that extended into the crowd.

A video of famous folks sharing their favorite Rolling Stones memories played before the band took the stage, with Johnny Depp, Martin Scorsese, Perry Farrell and others reminiscing about their favorite tunes.

Actress Cate Blanchett recalled "just how skinny they were."

"It really, really pisses me off," she said.

(Honestly, the Stones could produce a best-selling diet book ? the members are as slim as they were as aspiring rockers in the 1960s.)

Other videos showed the aging rockers as young men.

Jack Nicholson was among the stars in the audience, and fans welcomed him with a round of applause as he took his seat.

"It was either us or the Lakers, so now you got us," Jagger said early in the show, referring to the basketball playoffs that forced the band to postpone its opening concert from Thursday to Friday.

"It doesn't matter to Jack Nicholson," Jagger continued, "because he was coming to both of them."

Nicholson wasn't the only star in the house. Gwen Stefani, wearing long blond hair and a bedazzled Rolling Stones tank top, joined the group onstage to sing "Wild Horses."

"I've got to get one of these T-shirts," Jagger said, admiring her top.

Keith Urban played guitar and sang backup on "Respectable." Former Stones member Mick Taylor added guitar to "Midnight Rambler."

Richards sang a pair of tunes: "Happy" and "Before They Make Me Run." Jagger also played guitar and harmonica, and came out in a floor-length marabou cape to perform "Sympathy for the Devil."

"We first played in LA in 1965," Jagger said. "Thank you for keeping on coming to see us."

The Rolling Stones' tour continues through June 21.

___

Follow AP Entertainment Writer Sandy Cohen on Twitter: www.twitter.com/APSandy.

___

Online:

www.rollingstones.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-05-04-Music-Rolling%20Stones/id-af2d28dc7d824b2094edb1f9e3534b97

What is a Jesuit pi day Samsung Galaxy S4 St Francis Anquan Boldin Pope Benedict Jesuits

Tesla CEO amends Model S financing deal after criticism

By Deepa Seetharaman

DETROIT (Reuters) - Tesla Motors Inc, the automaker led by billionaire Elon Musk, overhauled financing strategy for the Model S electric sedan in response to criticism that its initial plan last month overstated the potential cost savings.

Changes include allowing buyers 72 months, instead of 63, to repay loans, lowering monthly costs by more than one-fourth. Tesla also guaranteed that the resale value of the Model S would top other luxury cars in its segment.

"We looked at it and decided we were wrong," Chief Executive Musk told reporters during a conference call on Friday. "Other people were right, and we needed to fix it."

The financing deal is intended to make the Model S electric sedan, which starts around $70,000 before a $7,500 tax credit, more affordable.

But Tesla got flack from critics who said the company was too aggressive in saying payments could be as low as $500 a month. The company's online payment calculator valued time saved filling up on gas at $100 an hour.

The automaker also drew criticism for pegging the resale value of the Model S to the Mercedes S class of sedans.

Tesla has since changed the default settings of its online payment calculators to be more conservative. The calculator now reflects only potential gas savings and assumes premium gas will be below $5 a gallon over the next three years.

Tesla will also guarantee that the resale value of the Model S will be higher than comparable luxury vehicles from BMW , Audi , Mercedes , Lexus or Jaguar , the company said.

"We're guaranteeing that the resale value in three years will be better than that of any of the major premium sedan brands," Musk told reporters.

Without taking into account gas savings, the monthly cost of owning a Model S will be around $800, down from $1,100, Musk said during the call. Including gas savings, the cost will be between $500 and $600 a month.

If 70 percent of the miles put on the car are for business purposes, the depreciation benefits cuts the "effective monthly cost" of owning a Model S down to $350, Tesla said.

The new financing deal will be extended to those who financed their Model S purchases over the last month. At least one-fifth of buyers over the last month made use of the financing deal, but Musk told reporters that he expects that figure to go as high as 70 percent.

(Reporting by Deepa Seetharaman; editing by Gunna Dickson)

Source: http://news.yahoo.com/tesla-ceo-amends-model-financing-deal-criticism-200436877.html

jeremy lin game winner chocolate covered strawberries shrimp scampi kate upton si cover lobster recipes hearts flower delivery

Saturday, May 4, 2013

Acer Aspire R7 Hands On: We're Not Quite Ready for This Kind of Crazy

Can we start by saying the R7 is nuts, and that that's totally great? Because it is, it's great that Acer's doing this weird new thing that doesn't exactly make sense, just to see if it works.

The very first thing you notice about the R7 becomes at once one of the the most and least important things about using it: the Ezel hinge. It's very godo at some of its jobs, and not very good at others. The problem is that it's got more to dot han the typical hinge. It's got to not only open and close like a typical laptop, but adjust forward and backward like an actual easel. Angling the screen with the top part of the hinge feels perfect. Tilting and flipping it all the way around to the other side (a novelty, but one you might actually use) takes just the right amount of force. But while you'll appreciate the back/bottom part of the hinge being so rigid while you're using the R7 as a touchscreen monitor?there's no wobble at all?it makes opening and closing the lid, and further, adjusting it forward or backwards, pretty inconvenient. That sounds like a small detail, and plenty of people won't mind a clumsy, two-handed process adjusting the hinge, but it's something you'll be doing quite often, given the trackpad placement.

About that. I'm not sure it makes that much ergonomic sense. The unit I used was on a raised box?about the level of a standing desk?and I didn't get to sit down with it on my lap. But I got the sense that the preferred use method is going to be with the screen mostly covering up the trackpad. That's where you'll see some benefit from the design, but it's still questionable, given standard placement would allow your hands to still be near the screen, but still have access tot he trackpad. And on the lap, where the wrist rests can also act as a stabilizing mechanism, this makes even less sense. There's definitely a type of user who's going to love this, though.

The most disappointing thing about the R7, though, is that despite its naming lineage, it seems like a big step backward from the S7 in build quality. It's sturdy, to be sure, but its plasticy and uncomfortable keyboard are a step back from the S7's, which was polarizing as far as usability, but always felt and looked premium. The 1080p 15-inch screen is very pretty, though large enough to be goofy when folded all the way down in tablet mode. It's not overly heavy, for a 15-inch device, but it ain't light, either.

The R7 is pretty clearly aimed at people who will be using it at a desk all day, and who have some compelling reason to be using touch over other input methods. It doesn't really make much sense for anyone else. For now, that first group is small enough to not register on a wide scale. That might not be the case in the future, but for now, the R7 really isn't for everyone.

Source: http://gizmodo.com/acer-aspire-r7-hands-on-crazy-is-the-future-but-not-q-489120346

amanda bynes dui ghost ship tiger woods masters jet crash virginia beach petrino clayton kershaw tyler perry

90 percent of pediatric specialists not following clinical guidelines when treating preschoolers with ADHD

90 percent of pediatric specialists not following clinical guidelines when treating preschoolers with ADHD [ Back to EurekAlert! ] Public release date: 4-May-2013
[ | E-mail | Share Share ]

Contact: Terry Lynam
tlynam@nshs.edu
516-465-2600
North Shore-Long Island Jewish (LIJ) Health System

Some prescribe medication too soon; others not even as a second-line treatment

NEW HYDE PARK, NY A recent study by pediatricians from the Cohen Children's Medical Center of New York examined to what extent pediatric physicians adhere to American Academy of Pediatrics (AAP) clinical guidelines regarding pharmacotherapy in treating young patients with Attention Deficit Hyperactivity Disorder (ADHD). The results showed that more than 90 percent of medical specialists who diagnose and manage ADHD in preschoolers do not follow treatment guidelines recently published by the AAP.

"It is unclear why so many physicians who specialize in the management of ADHD -- child neurologists, psychiatrists and developmental pediatricians -- fail to comply with recently published treatment guidelines," said Andrew Adesman, MD, senior investigator and chief of developmental and behavioral pediatrics at Cohen Children's Medical Center in New Hyde Park. "With the AAP now extending its diagnosis and treatment guidelines down to preschoolers, it is likely that more young children will be diagnosed with ADHD even before entering kindergarten. Primary care physicians and pediatric specialists should recommend behavior therapy as the first line treatment."

Current clinical guidelines for pediatricians and child psychiatrists associated with the American Academy of Child & Adolescent Psychiatry (AACAP) recommend that behavior therapy be the initial treatment approach for preschoolers with ADHD, and that treatment with medication should only be pursued when counseling in behavior management is not successful.

The study also found that more than one-in-five specialists who diagnose and manage ADHD in preschoolers recommend pharmacotherapy as a first-line treatment alone or in conjunction with behavior therapy. Although the AAP recommends that pediatricians prescribe methylphenidate when medication is indicated, more than one-third of specialists who prescribe medication for preschool ADHD said they 'often' or 'very often' choose a medication other than methylphenidate initially (19.4 percent amphetamines; 18.9 percent non-stimulants).

"Although the AAP's new ADHD guidelines were developed for primary care pediatricians, it is clear that many medical subspecialists who care for young children with ADHD fail to follow recently published guidelines," said Jaeah Chung, MD, the study's principal investigator who also practices at Cohen Children's. "At a time when there are public and professional concerns about over-medication of young children with ADHD, it seems that many medical specialists are recommending medication as part of their initial treatment plan for these children."

###

To schedule an interview with Dr. Adesman, call 516-232-5229 or email Adesman@lij.edu.

To view the abstract, "Medication Management of Preschool ADHD by Pediatric Sub-Specialists: Non-Compliance with AAP Clinical Guideline, go to http://www.abstracts2view.com/pas/view.php?nu=PAS13L1_1365.5

This study is being presented at the Pediatric Academic Societies in Washington, D.C. on Saturday May 4, 2013 11:30-11:45 a.m. at the Walter E. Washington Convention Center (Rm. 102B).


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


90 percent of pediatric specialists not following clinical guidelines when treating preschoolers with ADHD [ Back to EurekAlert! ] Public release date: 4-May-2013
[ | E-mail | Share Share ]

Contact: Terry Lynam
tlynam@nshs.edu
516-465-2600
North Shore-Long Island Jewish (LIJ) Health System

Some prescribe medication too soon; others not even as a second-line treatment

NEW HYDE PARK, NY A recent study by pediatricians from the Cohen Children's Medical Center of New York examined to what extent pediatric physicians adhere to American Academy of Pediatrics (AAP) clinical guidelines regarding pharmacotherapy in treating young patients with Attention Deficit Hyperactivity Disorder (ADHD). The results showed that more than 90 percent of medical specialists who diagnose and manage ADHD in preschoolers do not follow treatment guidelines recently published by the AAP.

"It is unclear why so many physicians who specialize in the management of ADHD -- child neurologists, psychiatrists and developmental pediatricians -- fail to comply with recently published treatment guidelines," said Andrew Adesman, MD, senior investigator and chief of developmental and behavioral pediatrics at Cohen Children's Medical Center in New Hyde Park. "With the AAP now extending its diagnosis and treatment guidelines down to preschoolers, it is likely that more young children will be diagnosed with ADHD even before entering kindergarten. Primary care physicians and pediatric specialists should recommend behavior therapy as the first line treatment."

Current clinical guidelines for pediatricians and child psychiatrists associated with the American Academy of Child & Adolescent Psychiatry (AACAP) recommend that behavior therapy be the initial treatment approach for preschoolers with ADHD, and that treatment with medication should only be pursued when counseling in behavior management is not successful.

The study also found that more than one-in-five specialists who diagnose and manage ADHD in preschoolers recommend pharmacotherapy as a first-line treatment alone or in conjunction with behavior therapy. Although the AAP recommends that pediatricians prescribe methylphenidate when medication is indicated, more than one-third of specialists who prescribe medication for preschool ADHD said they 'often' or 'very often' choose a medication other than methylphenidate initially (19.4 percent amphetamines; 18.9 percent non-stimulants).

"Although the AAP's new ADHD guidelines were developed for primary care pediatricians, it is clear that many medical subspecialists who care for young children with ADHD fail to follow recently published guidelines," said Jaeah Chung, MD, the study's principal investigator who also practices at Cohen Children's. "At a time when there are public and professional concerns about over-medication of young children with ADHD, it seems that many medical specialists are recommending medication as part of their initial treatment plan for these children."

###

To schedule an interview with Dr. Adesman, call 516-232-5229 or email Adesman@lij.edu.

To view the abstract, "Medication Management of Preschool ADHD by Pediatric Sub-Specialists: Non-Compliance with AAP Clinical Guideline, go to http://www.abstracts2view.com/pas/view.php?nu=PAS13L1_1365.5

This study is being presented at the Pediatric Academic Societies in Washington, D.C. on Saturday May 4, 2013 11:30-11:45 a.m. at the Walter E. Washington Convention Center (Rm. 102B).


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-05/nsij-9op050113.php

buckyballs buckyballs awake mario batali lone ranger aaron brooks dave matthews band

Citrix Launches Podio Chat To Bring Instant Messages, Video And Audio Chat To Its Social Business Platform

logo-podio-blue-CMYKCitrix today added a new real-time chat feature to its Podio social business platform that allows users to discuss projects, tasks, documents and other items by using standard instant messages, as well as audio and video chats. Citrix argues that this makes Podio, which was already being used by over 200,000 companies at the end of last year, “the first collaboration service of its kind to provide IM and video chat ?in context.? While Podio, which Citrix acquired last year, is quite a fully featured business platform and already included a number of real-time features, including real-time comments, the new chat feature allows for one-on-one and group chats. It features all of the usual chat features you’ve likely seen on Yammer or tools like Convo, including the ability to like comments. Citrix notes that Podio Chat is unique in its ability to bring text, audio and video chat together in one platform. Because Podio also allows you to invite users from outside of the company (contractors, suppliers, partners, etc.), the new chat feature should also make it easier and faster to work with them. As for the video chat tool, Citrix says that it will allow for ad-hoc, face-to-face discussion, as well as allow you to set up recurring team video meetings using the company’s GoToMeeting service. This feature, Citrix says, will allow businesses to unify their communications on its Podio platform “by enabling teams to communicate in a variety of different ways to get work done, all without email or third-party communication tools.” The new chat features will be available on the desktop, where it will live in a new chat pane, as well as on Podio’s mobile apps for Android and iOS.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/b9X7cW_JLQk/

foot locker champs champs calvin johnson calvin johnson sound of music Peter Billingsley

Friday, May 3, 2013

Newtown officials discuss plans for Sandy Hook school

NEWTOWN, Conn. (AP) ? Newtown, Conn., officials are meeting to discuss what to do with the elementary school where 20 first-graders and six educators were shot to death in December, but they might not vote.

A consultant for the town said a task force of 28 local elected officials likely wouldn't make a decision Friday night and will return for another meeting next week.

Residents have expressed mixed opinions on what should be done with Sandy Hook Elementary School.

The task force has narrowed a list of choices to renovating or rebuilding on the school site or building a new school on property down the street.

The 430 surviving students are attending a renovated school renamed Sandy Hook Elementary School in the neighboring town of Monroe.

Source: http://news.yahoo.com/newtown-board-mulls-plans-sandy-hook-school-002903689.html

mike the situation jacksonville jaguars jacksonville jaguars benjarvus green ellis shaka smart hungergames bagpipes

Pride and Prejudice and Zombies Lives Again

lily collins burr steers pride prejudice and zombies

The adaptation of?Seth Grahame-Smith?s novel Pride and Prejudice and Zombies has inspired countless undead puns with its talent troubles.? Natalie Portman was originally attached to star, but dropped out (she is still producing).? Since then, the lead role has been offered to the likes of Anne Hathaway, Mia Wasikowska, Scarlett Johansson, Emma Stone, and Blake Lively?no takers.? Meanwhile, David O. Russell, Mike White, and Craig Gillespie all signed on to direct at one point before they eventually departed the project.

Panorama Media recently came on board to produce and finance the picture.? First step: Drop the first ?and? so it?s just Pride, Prejudice and Zombies.? Next step: Sign a director and star.? Variety reports that Burr Steers (Charlie St. Cloud) is set to direct and Lily Collins (Mirror Mirror) is in talks to play Elizabeth Bennet.? Much as I like Collins, it?s clear the producers have lowered their sights a bit from the Russell/Portman days?hopefully Steers and Collins will be easier to handcuff to the project.? Read the book synopsis after the jump.

pride and prejudice and zombies book cover

?It is a truth universally acknowledged that a zombie in possession of brains must be in want of more brains.? So begins Pride and Prejudice and Zombies, an expanded edition of the beloved Jane Austen novel featuring all-new scenes of bone-crunching zombie mayhem. As our story opens, a mysterious plague has fallen upon the quiet English village of Meryton and the dead are returning to life! Feisty heroine Elizabeth Bennet is determined to wipe out the zombie menace, but she?s soon distracted by the arrival of the haughty and arrogant Mr. Darcy.

What ensues is a delightful comedy of manners with plenty of civilized sparring between the two young lovers and even more violent sparring on the blood-soaked battlefield as Elizabeth wages war against hordes of flesh-eating undead. Can she vanquish the spawn of Satan? And overcome the social prejudices of the class-conscious landed gentry?? [Amazon].

?

Source: http://www.rottentomatoes.com/m/1927385/news/1927385/

chris carpenter dick cheney hcg drops reason rally mad hatter azerbaijan ryan howard

This 3D-Printed Cyborg Ear Comes With a Built-In Antenna

While still not entirely commonplace, 3D-printed body parts made of actual, living tissue have started popping up at a wonderfully alarming rate. The most recent iteration, though, takes the concept one whole cyborg-tinged step further. Researchers at Princeton successfully created a prototype, artificial ear that rolls 3D-printed cells in with an antenna for one terrifyingly awesome hearing aid.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/FWTv6GkMaik/this-3d-printed-cyborg-ear-comes-with-a-built-in-antenn-487183299

george lopez bedtime stories micron amanda knox chris kelly blackhawks

Winds spur new wildfires near Calif. homes

Rincon Valley fire captain Fred Leunberger watches as a pine tree torches out on the head of the Yellow fire above Knights Valley, Calif., Wednesday, May 1, 2013. The fire started early Wednesday morning on the rugged border between Napa and Sonoma Counties and roared through tall stands of pine trees. Crews were securing the perimeter of the fire in the afternoon. (AP Photo/Santa Rosa Press Democrat, Kent Porter)

Rincon Valley fire captain Fred Leunberger watches as a pine tree torches out on the head of the Yellow fire above Knights Valley, Calif., Wednesday, May 1, 2013. The fire started early Wednesday morning on the rugged border between Napa and Sonoma Counties and roared through tall stands of pine trees. Crews were securing the perimeter of the fire in the afternoon. (AP Photo/Santa Rosa Press Democrat, Kent Porter)

A firefighter puts out the remaining hot spots in the one building that has burned as a result of a brush fire burning in the hills above Banning, Calif., on Wednesday, May 1, 2013. (AP Photo/The Press-Enterprise, Terry Pierson)

A resident carries a bucket of water to help fight the brush fire burning right up to his property in the hills above Banning, Calif., on Wednesday, May 1, 2013. (AP Photo/The Press-Enterprise, Terry Pierson)

Flames scorch the hillside north of Banning, Calif., as a brush fire burns in the area Wednesday, May 1, 2013. (AP Photo/The Press-Enterprise, Terry Pierson)

Rincon Valley firefighter Nate DeJung keeps check on the head of the Yellow fire above Knights Valley, Calif., Wednesday May 1, 2013. The fire started early Wednesday morning on the rugged border between Napa and Sonoma Counties and roared through tall stands of pine trees. Crews were securing the perimeter of the fire in the afternoon. (AP Photo/Santa Rosa Press Democrat, Kent Porter)

(AP) ? Authorities have ordered evacuations of a neighborhood and a university about 50 miles west of Los Angeles where a wildfire is raging close to subdivisions.

The blaze on the fringes of Camarillo and Thousand Oaks broke out Thursday morning and was quickly spread by gusty Santa Ana winds. Evacuation orders include California State University, Channel Islands.

About 100 miles to the east, four residences have burned in a grass fire that has prompted the evacuation of an elementary school in Jurupa Valley.

Other fires are burning around the state with various degrees of containment.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-05-02-California%20Wildfires/id-46751736767f47baa0d148f1e4734526

Johnny Manziel ups Aj Mccarron Girlfriend linkedin linkedin CES 2013 joe budden

Thursday, May 2, 2013

Simple Ideas That Have Big Impacts For Home Businesses ...

Online resources can impart lots of useful knowledge. Learning how to properly run a home-based business is easy to do by going online. This article is one of many that can be useful in helping your home business.

If you must take clients out, you can itemize these expenses. Meetings with business associates are deemed legal business costs. Make sure that any of the expenses that you deduct in this way are due to meeting current or potential clients to make sure that the deductions are legit.

You should always include a banner page on your site. You will be able to exchange for your banners with outer webmasters. This provides more backlinks for boosting your search engine rankings, and helps potential customers find your site.

Write a short description of your business, focusing on your values and goals. Include the identity of your business as well as its goal. In your business objective, explain the unique standpoint of your business, as well as your goals for the company.

Set up a fund that you can use in case of emergency, in order to ensure your business? financial security. Doing this will give you a cushion that will let you cover unexpected expenses without it negatively effecting your business. Only take money from this fund when it is absolutely necessary and make sure that you replace the money at the first available opportunity.

Knowing how to market online is the key to good profits. You can market your business online by blogging, writing articles, or sending out an email newsletter. These actions will increase the traffic to your site and can lead to greater success.

If you desire to make lots of cash as a home based business owner, it?s vital that you know when to take chances. Trying out new things will bring in new customers and improve profit. Sticking to tried and true strategies is fine, but don?t be afraid to mix it up and see what works.

Search engine optimization is essential for making your home business enterprise more visible on the Internet. Search engine optimization, commonly referred to as SEO, helps to improve your visibility on the Internet. This can boost sales exponentially for home businesses. Look into guides for optimizing your own website, or look into hiring a professional to do it for you.

It is not too horribly hard to start up your business at home. There are many businesses you can start without a lot of cost involved. Think of services or products that you wish were available in your area and then look into what it would take to start that business.

When generating product ideas for your home based business, start by considering products that would fill your personal needs. A product or service that fills an everyday issue is one that will appeal to a good-sized customer market. By coming up with an answer for a dilemma you have personally experienced, it is likely that your idea will be easily marketable to others as well.

If you have a work from home business, make sure to hire a distinguished accountant. Go over this before you start your business, so you can accurately track everything that you spend. Your office space, driving costs and more are all deductions.

Home business owners tend to congregate online. Check out and research internet communities such as forums or message boards, and include both ones dedicated to your particular niche or outside your area of expertise. Solid advice where you can learn new lessons about operating your own business can come from many different areas, so you don?t want to limit yourself to only your niche.

With the information that has been shared with you in this article, you should have acquired knowledge that will aid in making your work from home business more successful. Reread this article as often as you feel is necessary. Apply what you?ve learned and get ready for success.

If you would enjoy additional information on this topic, visit:
Best network marketing opportunity.

Share and Enjoy

Source: http://mysparetime.net/simple-ideas-that-have-big-impacts-for-home-businesses/

cab calloway melissa gilbert deadliest catch dwts sean hannity bobby petrino fired buffett rule

Mo. GOPs at odds over what to do with extra money

JEFFERSON CITY, Mo. (AP) -- After coping through several lean years, Missouri's Republican legislative leaders now are at odds over whether to save or spend an apparent excess of money.

Senate Appropriations Committee Chairman Kurt Schaefer says he expects Missouri will end its fiscal year on June 30 with about $400 million more than had been projected. He wants to spend more than $200 million of that to replace an aging state mental hospital in Fulton.

But House Budget Committee Chairman Rick Stream, R-Kirkwood, prefers to save the money as cushion for next year's budget while waiting to see if the economy continues to improve.

The difference of opinion among Missouri's top legislative budget writers will have to be resolved soon. Lawmakers face a constitutional deadline of May 12 to send a budget to Gov. Jay Nixon for the fiscal year that starts July 1.

Schaefer, R-Columbia, has been pressing House members to revise the revenue projections agreed in December ? upon which the budget is based ? because tax revenues have been better than expected. But Stream and other House leaders have refused to do so.

"Being momentarily ahead of the consensus revenue estimate is not a good enough excuse to me to engage in a new large amount of additional spending," House Speaker Tim Jones, R-Eureka, told reporters Monday night. "I just don't see that that's fiscally prudent, fiscally conservative or anything the House has done in the past."

Schaefer contends House members are acting as if the excess revenues do not even exist.

"It's some kind of alternate reality in this building where generally accepted accounting principles don't seem to apply," Schaefer said.

Missourians should get an update soon about state revenues. Tuesday was the final day of April, and monthly revenue figures typically are released a few days after the close of the month.

Linda Luebbering, the budget director for Democratic Gov. Jay Nixon, has said previously that revenues are running ahead of projections, but that may diminish in coming months.

Source: http://news.yahoo.com/mo-gops-odds-over-extra-172446859.html

padma lakshmi daughtry lakers trade ann arbor news nick young elizabeth smart south dakota state

AMD FX-4350 and FX-6350 offer improved speeds, keep prices down

AMD FX-4350 and FX-6350 offer improved speeds, keep prices down

Although AMD hasn't had much recent success at the higher end of the processor spectrum, it's clear the company is very much interested in attacking the budget realm. Witness its two new lower-tiered FX-series processors: the quad-core FX-4350 and six-core FX-6350 bring noticeable (if modest) improvements over the FX-4300 and FX-6300 chips they effectively replace. Both unlocked CPUs up the base clock speed to 3.9GHz, while the Max Turbo speeds jump to a respective 4.3GHz and 4.2GHz each. The FX-4350 further trumps its ancestor by doubling the Level 3 cache to 8MB, albeit with a higher power draw. More importantly, prices aren't budging much at all in spite of the brisker performance. When the FX-4350 and FX-6350 cost just $122 and $132 each, they're cheap enough that DIY builders shouldn't weep when the bills are due.

Filed under: ,

Comments

Via: AMD Unprocessed

Source: AMD

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/UpsRSvdVjnk/

Pope Resigns westminster dog show Christopher Dorner Manifesto mardi gras Christopher Dorner whitney houston Salwa Amin

Monday, February 18, 2013

This Apple TV Concept Video Raises A Big Question About The Very Idea Of An Apple TV (AAPL)

Thanks to countless reports from analysts and others, we've all been expecting an Apple TV for a while now.

These days, Apple shareholders in particular would love to see one come out.

The smartphone market is pretty saturated now, and Apple needs another category to dominate.

But maybe we should all temper our enthusiasm.

A Russian Apple blogger just made a showing off his concept for an Apple TV. (A French Apple blogger spotted it.)

It's?kind of boring. It looks like a TV.

And maybe that's the problem?TVs all look pretty much the same ? great.

They're thin with big screens and small, out-of-the-way frames.

How is Apple going to improve on that?

With software, obviously.

But don't we already have Apple TV software? Isn't it called Apple TV? Isn't Apple TV rather unpopular?

Here's the video:

?

Please follow SAI on Twitter and Facebook.

See Also:

Source: http://www.ibtimes.com/node/1090394

j.k. rowling j.k. rowling axl rose google earnings pat burrell hilary rosen grilled cheese